TY  - BOOK
AU  - Cartwright,Terence
TI  - Animal cells as bioreactors
T2  - Cambridge studies in biotechnology
SN  - 9780511565069 (ebook)
AV  - TP248.27.A53 C37 1994
U1  - 615/.19 20
PY  - 1994///
CY  - Cambridge
PB  - Cambridge University Press
KW  - Animal cell biotechnology
KW  - Pharmaceutical biotechnology
N1  - Title from publisher's bibliographic system (viewed on 05 Oct 2015); Introducing the animal cell as a bioreactor -- Yields of recombinant product: engineering cells for maximum expression -- Generation of biomass -- Adjusting cellular metabolism for optimum product yield -- Downstream processing -- Regulatory aspects of using cells as bioreactors
N2  - Because of their complexity, the new generation of genetically engineered protein drugs can only be made by biotechnological methods, using cultures of animal cells. This book covers all aspects of the technologies needed to turn animal cells into an acceptable and cost-effective tool for drug production. This includes modifying them genetically so that they produce the right product in high yield, getting them to grow reproducibly on an industrial scale, and extracting the required product from them. It also covers biological safety issues, and the verification of the chemical and biological nature of the protein drug produced. The work covers developments in all of these areas and how they all need to be integrated for the design of an effective biotechnological production process. It therefore provides a comprehensive guide to this area of biotechnology
UR  - https://doi.org/10.1017/CBO9780511565069
ER  -