Statistical mechanics and stability of macromolecules :
Prohofsky, Earl,
Statistical mechanics and stability of macromolecules : application to bond disruption, base pair separation, melting, and drug dissociation of the DNA double helix / Statistical Mechanics & Stability of Macromolecules Earl Prohofsky. - Cambridge : Cambridge University Press, 1995. - 1 online resource (x, 227 pages) : digital, PDF file(s).
Title from publisher's bibliographic system (viewed on 05 Oct 2015).
This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.
9780511524721 (ebook)
DNA--Stability--Statistical methods.
Macromolecules--Stability--Statistical methods.
Statistical mechanics.
QP624.5.S73 / P76 1995
574.87/3282
Statistical mechanics and stability of macromolecules : application to bond disruption, base pair separation, melting, and drug dissociation of the DNA double helix / Statistical Mechanics & Stability of Macromolecules Earl Prohofsky. - Cambridge : Cambridge University Press, 1995. - 1 online resource (x, 227 pages) : digital, PDF file(s).
Title from publisher's bibliographic system (viewed on 05 Oct 2015).
This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.
9780511524721 (ebook)
DNA--Stability--Statistical methods.
Macromolecules--Stability--Statistical methods.
Statistical mechanics.
QP624.5.S73 / P76 1995
574.87/3282