Molecular oncology : (Record no. 518790)
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| 000 -LEADER | |
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| fixed length control field | 03832nam a22003738i 4500 |
| 001 - CONTROL NUMBER | |
| control field | CR9781139046947 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | UkCbUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200124160244.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION | |
| fixed length control field | m|||||o||d|||||||| |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr|||||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 110304s2014||||enk o ||1 0|eng|d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781139046947 (ebook) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 9780521876629 (hardback) |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | UkCbUP |
| Language of cataloging | eng |
| Description conventions | rda |
| Transcribing agency | UkCbUP |
| 050 00 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC268.4 |
| Item number | .M675 2014 |
| 082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99/4 |
| Edition number | 23 |
| 245 00 - TITLE STATEMENT | |
| Title | Molecular oncology : |
| Remainder of title | causes of cancer and targets for treatment / |
| Statement of responsibility, etc | edited by Edward P. Gelmann, chief, Division of Hematology/Oncology and deputy director for Clinical Research, Herbert Irving Comprehensive Cancer Center and Columbia University Medical Center, New York, NY, USA, Charles L. Sawyers, chair, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Frank J. Rauscher III, professor, Gene Expression and Regulation Program, professor, Tumor Microenvironment and Metastasis Program, deputy director for Basic Research, Wistar Institute Cancer Center, Philadelphia, PA, USA. |
| 264 #1 - Production, Publication, Distribution, Manufacture, and Copyright Notice (R) | |
| Place of production, publication, distribution, manufacture (R) | Cambridge : |
| Name of producer, publisher, distributor, manufacturer (R) | Cambridge University Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2014. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xxi, 961 pages) : |
| Other physical details | digital, PDF file(s). |
| 336 ## - Content Type (R) | |
| Content type term (R) | text |
| Content type code (R) | txt |
| Source (NR) | rdacontent |
| 337 ## - Media Type (R) | |
| Media type term (R) | computer |
| Media type code (R) | c |
| Source (NR) | rdamedia |
| 338 ## - Carrier Type (R) | |
| Carrier type term (R) | online resource |
| Carrier type code (R) | cr |
| Source (NR) | rdacarrier |
| 500 ## - GENERAL NOTE | |
| General note | Title from publisher's bibliographic system (viewed on 05 Oct 2015). |
| 505 2# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Part 1.1. Analytical techniques: analysis of DNA -- Part 1.2. Analytical techniques: analysis of RNA -- Part 2.1. Molecular pathways underlying carcinogenesis: signal transduction -- Part 2.2. Molecular pathways underlying carcinogenesis: apoptosis -- Part 2.3. Molecular pathways underlying carcinogenesis: nuclear receptors -- Part 2.4. Molecular pathways underlying carcinogenesis: DNA repair -- Part 2.5. Molecular pathways underlying carcinogenesis: cell cycle -- Part 2.6. Molecular pathways underlying carcinogenesis: other pathways -- Part 3.1. Molecular pathology: carcinomas -- Part 3.2. Molecular pathology: cancers of the nervous system -- Part 3.3. Molecular pathology: cancers of the skin -- Part 3.14 Molecular pathology: endocrine cancers -- Part 3.5. Molecular pathology: adult sarcomas -- Part 3.6. Molecular pathology:lymphoma and leukemia -- Part 3.7. Molecular pathology: pediatric solid tumors -- Part 4. Pharmacologic targeting of oncogenic pathways. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer |
| General subdivision | Molecular aspects. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Tumor markers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Carcinogenesis. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gelmann, Edward P., |
| Dates associated with a name | 1953- |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sawyers, Charles L., |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rauscher, F. J., |
| Titles and other words associated with a name | III |
| Fuller form of name | (Frank Joseph), |
| Dates associated with a name | 1957- |
| Relator term | editor. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| International Standard Book Number | 9780521876629 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1017/CBO9781139046947">https://doi.org/10.1017/CBO9781139046947</a> |
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