National Science Library of Georgia

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (Record no. 525007)

MARC details
000 -LEADER
fixed length control field 03791nam a22005415i 4500
001 - CONTROL NUMBER
control field 978-3-319-30030-6
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20200127152627.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 160419s2016 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783319300306
-- 978-3-319-30030-6
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-3-319-30030-6
Source of number or code doi
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QA71-90
072 #7 - SUBJECT CATEGORY CODE
Subject category code PDE
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code COM014000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code PDE
Source thema
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 004
Edition number 23
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Tveito, Aslak.
Relator term author.
Relator code aut
-- http://id.loc.gov/vocabulary/relators/aut
245 10 - TITLE STATEMENT
Title Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Medium [electronic resource] /
Statement of responsibility, etc by Aslak Tveito, Glenn T. Lines.
250 ## - EDITION STATEMENT
Edition statement 1st ed. 2016.
264 #1 - Production, Publication, Distribution, Manufacture, and Copyright Notice (R)
Place of production, publication, distribution, manufacture (R) Cham :
Name of producer, publisher, distributor, manufacturer (R) Springer International Publishing :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2016.
300 ## - PHYSICAL DESCRIPTION
Extent XVI, 261 p. 129 illus., 30 illus. in color.
Other physical details online resource.
336 ## - Content Type (R)
Content type term (R) text
Content type code (R) txt
Source (NR) rdacontent
337 ## - Media Type (R)
Media type term (R) computer
Media type code (R) c
Source (NR) rdamedia
338 ## - Carrier Type (R)
Carrier type term (R) online resource
Carrier type code (R) cr
Source (NR) rdacarrier
347 ## -
-- text file
-- PDF
-- rda
490 1# - SERIES STATEMENT
სერიის ცნობა Lecture Notes in Computational Science and Engineering,
International Standard Serial Number 1439-7358 ;
Volume number/sequential designation 111
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface -- Background: Contents and Method -- One-dimensional calcium release -- Models of open and state blockers -- Two-dimensional calcium release -- Computing theoretical drugs in the two-dimensional case -- Generalized systems -- Calcium-induced calcium release -- Numerical release for CICR -- A prototypical model of an ion channel -- Inactivated ion channels -- A simple model of the sodium channel -- Mutations affecting the mean open time -- The burst mode -- Whole sale action potentials -- .
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
520 ## - SUMMARY, ETC.
Summary, etc Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Computer mathematics.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Optical data processing.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Computational Science and Engineering.
-- http://scigraph.springernature.com/things/product-market-codes/M14026
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Biomedicine, general.
-- http://scigraph.springernature.com/things/product-market-codes/B0000X
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Computer Imaging, Vision, Pattern Recognition and Graphics.
-- http://scigraph.springernature.com/things/product-market-codes/I22005
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lines, Glenn T.
Relator term author.
Relator code aut
-- http://id.loc.gov/vocabulary/relators/aut
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783319300290
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783319300313
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9783319807089
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Lecture Notes in Computational Science and Engineering,
-- 1439-7358 ;
Volume number/sequential designation 111
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1007/978-3-319-30030-6">https://doi.org/10.1007/978-3-319-30030-6</a>
912 ## -
-- ZDB-2-SMA
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-- ZDB-2-SOB

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