Treatment-resistant mood disorders / edited by Jay D. Amsterdam, Mady Hornig, and Andrew A. Nierenberg.

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

The clinical problem -- The characterization and definition of treatment-resistant mood disorders / Daniel Souery, Olivier Lipp, Isabelle Massat, Julien Mendlewicz -- Overview of treatment-resistant depression and its management / John P. O'Reardon, Jay D. Amsterdam -- Biological basis -- Psychoneuroendocrine aspects of treatment-resistant mood disorders / Owen M. Wolkowitz, Victor I. Reus -- Estrogen and depressive illness in women / Barbara B. Sherwin -- Sleep abnormalities in treatment-resistant mood disorders / Martin P. Szuba, Antonio T. Fernando, Geralyn Groh-Szuba -- Structural and functional brain imaging in treatment-resistant depression / Terence A. Ketter, Christopher J. Bench, Mark S. George, Tim A. Kimbrell, Robert M. Post -- Immunologic factors in treatment-resistant depression / Anna Sluzewska, Janusz Rybakowski, Mady Hornig, Jay D. Amsterdam -- Treatment approaches -- Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression / William Boyer, Richard Bunt -- Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression / David Bakish, Cynthia L. Hooper -- Drug combination strategies / Lawrence H. Price, Linda L. Carpenter, Steven A. Rasmussen -- Electroconvulsive therapy in medication-resistant depression / Max Fink -- Thyroid augmentation / Russell T. Joffe -- Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders / Jan Scott, Robert J. DeRubeis -- Special patient populations.

While antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, so they have had to make difficult decisions about treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers and graduate students.