Epilepsy : models, mechanisms, and concepts / edited by Philip A. Schwartzkroin.

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

The kindling model of epilepsy / James O. McNamara, Douglas W. Bonhaus and Cheolsu Shin -- Focal trigger zones and pathways of propagation in seizure generation / Karen Gale -- Genetic models of the epilepsies / Phillip C. Jobe [and others] -- Noradrenergic modulation of excitability: transplantation approaches to epilepsy research / Olle Lindvall -- Sensitivity of the immature central nervous system to epileptogenic stimuli / Solomon L. Moshé, Patric K. Stanton and Ellen F. Sperber -- Neurophysiological studies of alterations in seizure susceptibility during brain development / John W. Swann [and others] -- Electrophysiology and pharmacology of human neocortex and hippocampus in vitro / Massimo Avoli -- Cell death, plasticity, and epilepsy: insights provided by experimental models of hippocampal sclerosis / JoAnn E. Franck -- Sprouting as an underlying cause of hyperexcitability in experimental models and in the human epileptic temporal lobe / Thomas P. Sutula -- Rapidly recurring seizures and status epilepticus: ictal density as a factor in epileptogenesis / Eric W. Lothman, Janet L. Stringer and Edward H. Bertram.

(cont.) Brain slice models for the study of seizures and interictal spikes / Wilkie A. Wilson and Andrew Bragdon -- Generation of epileptiform discharge by local circuits of neocortex / Barry W. Connors and Yael Amitai -- Study of GABAergic inhibition and GABA(sub A) receptors in experimental epilepsy / Robert K.S. Wong and Richard Miles -- High potassium-induced synchronous bursts and electrographic seizures / Christopher J. McBain, Stephen F. Traynelis and Raymond Dingledine -- Anti-epileptic effects of organic calcium channel blockers in animal experiments / Erwin-Josef Speckmann and Jörg Walden.

Advances in epilepsy research are occurring at a rapid rate, resulting in a bewildering wealth of data. The implications of this knowledge for future research and clinical practice can be confusing. This volume concentrates on the concepts and models of epilepsy which have been developed as a result of this research. Written by prominent researchers in the field, this book presents a number of major concepts and hypotheses through which epilepsy research has been advanced. Chapters focus on the pathways and mechanisms through which seizure activity is initiated and spread, in both normal and abnormal brain tissues, and discuss the special properties of epileptogenesis in the immature brain. In a field in which rapid advances lead to constant update of empirical data, this book takes a conceptual approach to the subject and provides a solid framework within which to understand the emerging issues. It will be relevant to basic neuroscientists, neurologists and neurosurgeons.