The biology of oligodendrocytes /
edited by Patricia J. Armati and Emily K. Mathey.
- Cambridge : Cambridge University Press, 2010.
- 1 online resource (xiii, 289 pages) : digital, PDF file(s).
Title from publisher's bibliographic system (viewed on 05 Oct 2015).
CNS oligarchs: the rise of the oligodendrocyte in a neuron-centric culture / Comparative biology of Schwann cells and oligodendrocytes / Control of oligodendrocyte development and myelination in the vertebrate CNS / Molecular organization of the oligodendrocyte and myelin / The genetics of oligodendrocytes / Immunobiology of the oligodendrocyte / Oligodendrocytes and disease: repair, remyelination and stem cells / Glial progenitor cells and the dynamics of the oligodendrocyte and its myelin in the aged and injured CNS / Oligodendroglial pathology in multiple sclerosis / Glutamate receptors, transporters, and periventricular leukomalacia / Emily Mathey, Ariel Arthur and Patricia Armati -- Rudolf Martini, Janos Groh and Udo Bartsch -- Robert H. Miller -- Grahame Kidd and Bruce D. Trapp -- Joseph A. Nielsen, Pierre Lau and Lynn D. Hudson -- David Kremer, Orhan Aktas, Hans-Peter Hartung and Patrick Küry -- Neil Scolding -- Jurate Lasiene and Philip J. Horner -- Tanja Kuhlmann and Wolfgang Brück -- Tara M. Desilva and Paul A. Rosenberg.
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.