TY - BOOK AU - Fersht,Alan TI - Enzyme structure and mechanism SN - 0716716143 AV - QP601 .F42 1985 U1 - 574.19/25 19 PY - 1985/// CY - New York PB - W.H. Freeman KW - Enzymes KW - ბიოლოგია KW - ბიოქიმია KW - ენზიმები - სტრუქტურა და მექანიზმი KW - ენზიმოლოგია N1 - Includes bibliographies and index; Contents: The three-dimensional structure of enzymes -- Chemical catalysis -- The basic equations of enzyme kinetics -- Management and magnitude of enzymatic rate constants -- The pH dependence of enzyme catalysis -- Practical kinetics -- Detection of intermediates in reactions by kinetics -- Stereochemistry of enzymatic reactions -- Active-site-directed and enzyme-activated irreversible inhibitors: "affinity labels" and "suicide inhibitors" -- Cooperative ligand binding, allosteric interactions, and regulation -- Forces between molecules, and enzyme-substrate binding energies -- Enzyme-substrate complementarity and the use of binding energy in catalysis -- Specificity and editing mechanisms -- Genetic engineering and enzymology: protein engineering -- Structures and mechanisms of selected enzymes ER -