Birth, distress, and disease : placental-brain interactions / edited by Michael L. Power and Jay Schulkin.

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Placental expression of neurohormones and other neuroactive molecules in human pregnancy -- The regulation of human parturition -- Maternal nutrition and metabolic control of pregnancy -- Fetal HPA activation, preterm birth and postnatal programming -- Prenatal glucocorticoids and the programming of adult disease -- Prenatal stress and stress physiology influences human fetal and infant development -- Glucocorticoids and the ups and downs of neuropeptide gene expression -- Glucocorticoid facilitation of corticotropin-releasing hormone in the placenta and the brain: functional impact on birth and behavior.

Originally published in 2005, this volume examines the role of steroids and peptides in the regulation of pregnancy and pregnancy outcome, and their long-term effects including possible influences on adult-onset diseases. During pregnancy the placenta acts as a central regulator and coordinator of maternal and fetal physiology, and the onset of labor, through its production and regulation of steroids and peptides. Perturbations to this regulatory system can result in poor pregnancy outcome, such as preterm birth and low birth weight. These in turn are linked to diseases in later life. Intriguingly, many of these regulatory actions of steroids and peptides also occur in the brain. The induction and suppression of peptides by steroids appears to be key to regulatory function in both brain and placenta. These interweaving strands, linking basic science with obstetrics, are all reviewed in depth here producing a fascinating account of an important area of materno-fetal medicine.