000			02708nam a22004098i 4500
001			CR9781139026451
003			UkCbUP
005			20200124160225.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			110218s2013||||enk o ||1 0|eng|d
020			_a9781139026451 (ebook)
020			_z9781107008809 (hardback)
020			_z9781107401358 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aR853.C55 _bG46 2013
082	0	0	_a610.72/4 _223
100	1		_aSimon, Richard M., _d1943- _eauthor.
245	1	0	_aGenomic clinical trials and predictive medicine / _cRichard M. Simon.
246	3		_aGenomic Clinical Trials & Predictive Medicine
264		1	_aCambridge : _bCambridge University Press, _c2013.
300			_a1 online resource (xiii, 144 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aPractical guides to biostatistics and epidemiology
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aClinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design.
520			_aGenomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients.
650		0	_aClinical trials _xStatistical methods.
650		0	_aGenomics _xStatistical methods.
650		0	_aTumor markers _xStatistical methods.
650		0	_aTherapeutics, Experimental _xStatistical methods.
776	0	8	_iPrint version: _z9781107008809
830		0	_aPractical guides to biostatistics and epidemiology.
856	4	0	_uhttps://doi.org/10.1017/CBO9781139026451
999			_c517058 _d517056