000			04179nam a22003978i 4500
001			CR9780511730405
003			UkCbUP
005			20200124160227.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			100308s2010||||enk o ||1 0|eng|d
020			_a9780511730405 (ebook)
020			_z9780521882330 (hardback)
020			_z9781107475854 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQH447.8.R47 _bM65 2010
082	0	0	_a572/.36 _222
245	0	0	_aMolecular imaging with reporter genes / _cedited by Sanjiv S. Gambhir, Shahriar S. Yaghoubi.
264		1	_aCambridge : _bCambridge University Press, _c2010.
300			_a1 online resource (xiii, 321 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aCambridge molecular imaging series
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	8		_aMachine generated contents note: Part I. Types of Imaging Reporter Genes: 1. Fluorescent proteins reporter Robert E. Campbell and Michael W. Davidson; 2. Revealing biomolecular mechanisms through in vivo bioluminescence imaging Timothy C. Doyle, Qian Wang, and Christopher H. Contag; 3. Reporter gene imaging with PET/SPECT June-Key Chung, Joo Hyun Kang, and Keon Wook Kang; 4. Non-invasive imaging genes and gene expression with magnetic resonance imaging and magnetic resonance spectroscopy James Basilion; Part II. Enhancing Reporter Gene Imaging Techniques: 5. Multimodality imaging reporter gene Pritha Ray and Sanjiv Sam Gambhir; 6. Cell-specific imaging of reporter gene expression using a two-step transcriptional amplification strategy Marxa L. Figueirdo, Sanjiv Sam Gambhir, Michael Carey, and Lily Wu; Part III. Imaging Instrumentations: 7. Physics, instrumentation, and methods for imaging reporter gene expression in living subjects Craig S. Levin; Part IV. Current Applications of Imaging Reporter Genes: 8. Reporter gene imaging of cell signal transduction Tarik F. Massoud, Ramasamy Paulmurugan, Carmel Chan, Hua Fan-Minogue, and Sanjiv Sam Gambhir; 9. Gene therapy and imaging of transgene expression in living subjects Shahrihar S. Yaghoubi and Sanjiv Sam Gambhir; 10. Imaging regulation of endogenous gene expression in living subjects Vladimir Ponomarev; 11. Imaging cell trafficking and immune cell activation using PET reporter genes Evan D. Nair-Gill, Chengyi J. Shu, Isabel J. Hildebrandt, Dean O. Campbell, Owen N. Witte, and Caius G. Radu; 12. Imaging reporter genes and stem cells Martin G. Rodriguez-Porcel; 13. Clinical applications of reporter gene technology Ivan Penuelas, Shahriar S. Yaghoubi, Felipe Prosper, and Sanjiv Sam Gambhir.
520			_aReporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
650		0	_aReporter genes.
650		0	_aMolecular probes.
650		0	_aDiagnostic imaging.
700	1		_aGambhir, Sanjiv Sam, _eeditor.
700	1		_aYaghoubi, Shahriar S. _q(Shahriar Shah), _d1975- _eeditor.
776	0	8	_iPrint version: _z9780521882330
830		0	_aCambridge molecular imaging series.
856	4	0	_uhttps://doi.org/10.1017/CBO9780511730405
999			_c517277 _d517275