000 02474nam a22003738i 4500
001 CR9780511529702
003 UkCbUP
005 20200124160233.0
006 m|||||o||d||||||||
007 cr||||||||||||
008 090409s1986||||enk o ||1 0|eng|d
020 _a9780511529702 (ebook)
020 _z9780521254649 (hardback)
020 _z9780521038096 (paperback)
040 _aUkCbUP
_beng
_erda
_cUkCbUP
050 0 0 _aRB155
_b.E77 1986
082 0 0 _a616/.042
_219
100 1 _aEpstein, Charles J.,
_eauthor.
245 1 4 _aThe consequences of chromosome imbalance :
_bprinciples, mechanisms, and models /
_cCharles J. Epstein.
264 1 _aCambridge :
_bCambridge University Press,
_c1986.
300 _a1 online resource (xxi, 486 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aDevelopmental and cell biology series ;
_v18
500 _aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
520 _aThis book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.
650 0 _aAneuploidy.
650 0 _aHuman chromosome abnormalities.
650 0 _aDown syndrome
_xGenetic aspects.
776 0 8 _iPrint version:
_z9780521254649
830 0 _aDevelopmental and cell biology series ;
_v18.
856 4 0 _uhttps://doi.org/10.1017/CBO9780511529702
999 _c517777
_d517775