000			03221nam a22004098i 4500
001			CR9780511529733
003			UkCbUP
005			20200124160237.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090409s2002||||enk o ||1 0|eng|d
020			_a9780511529733 (ebook)
020			_z9780521584456 (hardback)
020			_z9780521018357 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQH470.D7 _bH45 2002
082	0	0	_a576.5 _221
100	1		_aHeld, Lewis I., _cJr., _d1951- _eauthor.
245	1	0	_aImaginal discs : _bthe genetic and cellular logic of pattern formation / _cLewis I. Held, Jr.
264		1	_aCambridge : _bCambridge University Press, _c2002.
300			_a1 online resource (xv, 460 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aDevelopmental and cell biology series ; _v39
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0	0	_gCh. 1. _tCell Lineage vs. Intercellular Signaling. _tDiscs are not clones. _tNo part of a disc is a clone, except claws and tiny sense organs. _tCells belong to lineage "compartments" -- _gCh. 2. _tThe Bristle. _tNumb segregates asymmetrically and dictates bristle cell fates. _tDelta needs to activate Notch, but not as a signal per se. _tAmnesic cells can use sequential gating to simulate a binary code. _tNotch must go to the nucleus to function. _tE(spl)-C genes are Su(H) targets but play no role in the SOP lineage. _tThe transcription factor Tramtrack implements some cell identities. _tHairless titrated Su(H). _tSeveral other genes help determine the 5 cell fates. _tPox neuro and Cut specify bristle type. _tBract cells are induced by bristle cells.
520			_aMany of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.
650		0	_aDrosophila melanogaster _xGenetics.
650		0	_aDrosophila melanogaster _xEmbryology.
650		0	_aDrosophila melanogaster _xMorphogenesis _xMolecular aspects.
650		0	_aCellular signal transduction.
650		0	_aCell interaction.
776	0	8	_iPrint version: _z9780521584456
830		0	_aDevelopmental and cell biology series ; _v39.
856	4	0	_uhttps://doi.org/10.1017/CBO9780511529733
999			_c518217 _d518215