000			03832nam a22003738i 4500
001			CR9781139046947
003			UkCbUP
005			20200124160244.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			110304s2014||||enk o ||1 0|eng|d
020			_a9781139046947 (ebook)
020			_z9780521876629 (hardback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aRC268.4 _b.M675 2014
082	0	0	_a616.99/4 _223
245	0	0	_aMolecular oncology : _bcauses of cancer and targets for treatment / _cedited by Edward P. Gelmann, chief, Division of Hematology/Oncology and deputy director for Clinical Research, Herbert Irving Comprehensive Cancer Center and Columbia University Medical Center, New York, NY, USA, Charles L. Sawyers, chair, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Frank J. Rauscher III, professor, Gene Expression and Regulation Program, professor, Tumor Microenvironment and Metastasis Program, deputy director for Basic Research, Wistar Institute Cancer Center, Philadelphia, PA, USA.
264		1	_aCambridge : _bCambridge University Press, _c2014.
300			_a1 online resource (xxi, 961 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	2		_aPart 1.1. Analytical techniques: analysis of DNA -- Part 1.2. Analytical techniques: analysis of RNA -- Part 2.1. Molecular pathways underlying carcinogenesis: signal transduction -- Part 2.2. Molecular pathways underlying carcinogenesis: apoptosis -- Part 2.3. Molecular pathways underlying carcinogenesis: nuclear receptors -- Part 2.4. Molecular pathways underlying carcinogenesis: DNA repair -- Part 2.5. Molecular pathways underlying carcinogenesis: cell cycle -- Part 2.6. Molecular pathways underlying carcinogenesis: other pathways -- Part 3.1. Molecular pathology: carcinomas -- Part 3.2. Molecular pathology: cancers of the nervous system -- Part 3.3. Molecular pathology: cancers of the skin -- Part 3.14 Molecular pathology: endocrine cancers -- Part 3.5. Molecular pathology: adult sarcomas -- Part 3.6. Molecular pathology:lymphoma and leukemia -- Part 3.7. Molecular pathology: pediatric solid tumors -- Part 4. Pharmacologic targeting of oncogenic pathways.
520			_aThe genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target.
650		0	_aCancer _xMolecular aspects.
650		0	_aTumor markers.
650		0	_aCarcinogenesis.
700	1		_aGelmann, Edward P., _d1953- _eeditor.
700	1		_aSawyers, Charles L., _eeditor.
700	1		_aRauscher, F. J., _cIII _q(Frank Joseph), _d1957- _eeditor.
776	0	8	_iPrint version: _z9780521876629
856	4	0	_uhttps://doi.org/10.1017/CBO9781139046947
999			_c518790 _d518788