000			02749nam a22003618i 4500
001			CR9780511663543
003			UkCbUP
005			20200124160311.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			091216s2005||||enk o ||1 0|eng|d
020			_a9780511663543 (ebook)
020			_z9780521529563 (hardback)
020			_z9780521159449 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQH671 _b.A6576 2005
082	0	0	_a571.9/36 _222
245	0	0	_aApoptosis in health and disease : _bclinical and therapeutic aspects / _cedited by Martin Holcik [and others].
246	3		_aApoptosis in Health & Disease
264		1	_aCambridge : _bCambridge University Press, _c2005.
300			_a1 online resource (ix, 249 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aApoptosis in health, disease and therapy: overview and methodology -- Developmental apoptosis in health and disease -- Apoptosis and cancer -- Neuronal cell death in human neurodegenerative diseases and their animal/cell models -- Apoptosis in the cardiovascular system: incidence, regulation, and therapeutic options -- Cytotoxic lymphocytes, apoptosis, and autoimmunity -- Pro- and anti-apoptotic strategies of viruses.
520			_aThe process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.
650		0	_aApoptosis.
650		0	_aPathology, Cellular.
700	1		_aHolcik, Martin, _d1967- _eeditor.
776	0	8	_iPrint version: _z9780521529563
856	4	0	_uhttps://doi.org/10.1017/CBO9780511663543
999			_c521056 _d521054