000 02686nam a22003258i 4500
001 CR9780511770579
003 UkCbUP
005 20200124160317.0
006 m|||||o||d||||||||
007 cr||||||||||||
008 100510s2010||||enk o ||1 0|eng|d
020 _a9780511770579 (ebook)
020 _z9780521114523 (hardback)
040 _aUkCbUP
_beng
_erda
_cUkCbUP
050 0 4 _aQP451.4
_b.L46 2010
082 0 0 _a616/.0472
_222
100 1 _aLenz, Frederick A.,
_eauthor.
245 1 4 _aThe human pain system :
_bexperimental and clinical perspectives /
_cFrederick A. Lenz [and others].
264 1 _aCambridge :
_bCambridge University Press,
_c2010.
300 _a1 online resource (x, 638 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505 0 _aDiscovery of the anterolateral system and its role as a pain pathway -- Organization of the central pain pathways -- Physiology of cells of origin of spinal cord and brainstem projections -- Physiology of supraspinal pain, related structures -- Functional brain imaging of acute pain in healthy humans -- Pain modulatory systems -- Peripheral and central mechanisms and manifestations of chronic pain and sensitization -- Functional imaging of chronic pain -- Functional implications of spinal and forebrain procedures for the treatment of chronic pain.
520 _aPain is a subject of significant scientific and clinical interest. This has resulted both from realistic rodent models, and the publication of imaging, psychological and pharmacological studies in humans. Investigators studying rodents refer to anatomical and physiological studies in non-human primates to make their results relevant to humans. Psychophysical and pharmacological studies in humans are interpreted in terms of anatomical and physiological studies in animals; primarily evidence from rodents and cats. There are significant differences in pain mechanisms between these species and primates. Over 20 years of imaging studies have demonstrated the activation of human cortical and subcortical structures in response to painful stimuli. Interpretation of these results relies upon an understanding of the anatomy and physiology of these structures in primates. Jones, Lenz, Casey and Willis review the anatomy and physiology of nociception in monkeys and humans, and provide a firm basis for interpreting studies in humans.
650 0 _aPain.
776 0 8 _iPrint version:
_z9780521114523
856 4 0 _uhttps://doi.org/10.1017/CBO9780511770579
999 _c521537
_d521535