000			04258nam a22003378i 4500
001			CR9780511596773
003			UkCbUP
005			20200124160319.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090716s2009||||enk o ||1 0|eng|d
020			_a9780511596773 (ebook)
020			_z9780521887328 (hardback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aRM282.M65 _bR43 2009
082	0	0	_a615/.37 _222
245	0	0	_aRecombinant antibodies for immunotherapy / _cedited by Melvyn Little.
264		1	_aCambridge : _bCambridge University Press, _c2009.
300			_a1 online resource (xiv, 419 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aHumanization of recombinant antibodies / José W. Saldanha -- Immunogenicity assessment of antibody therapeutics / Philippe Stas [and others] -- In vitro screening for antibody immunogenicity / Frank J. Carr and Matthew B. Baker -- Antibody libraries from naïve V gene sources / Gerald Beste and David Lowe -- Antibodies from IgM libraries / Stefan Knackmuss and Vera Molkenthin -- Generation and screening of synthetic human combinatorial antibody library HuCAL GOLD / Ingo M. Klagge -- Therapeutic antibodies from XenoMouse transgenic mice / Aya Jakobovits -- VelocImmune : immunoglobulin variable region humanized mice / Andrew Murphy -- Mechanisms of tumour cell killing by therapeutic antibodies / Ross Stewart and Carl Webster -- Optimization of Fc domains to enhance antibody therapeutics / Greg A. Lazar and Aaron K. Chamberlain -- Glycoengineered therapeutic antibodies / Peter Brünker, Peter Sondermann, and Pablo Umaña -- Monoclonal antibodies for the delivery of cytotoxic drugs / David J. King.
505	0		_aImmunotherapy with radio-immune conjugates / Christina A. Kousparou and Agamemnon A. Epenetos -- Immunotherapeutic antibody fusion proteins / Nigel S. Courtenay-Luck and David Jones -- Alternative antibody formats / Fabrice Le Gall and Melvyn Little -- Single-domain antibodies / Serge Muyldermans, Gholamreza Hassanzadeh Ghassabeh, and Dirk Saerens -- Engineering of non-CDR loops in immunoglobulin domains / Florian Rüker and Gordana Wozniak-Knopp -- Alternative scaffolds : expanding the options of antibodies / Andreas Plückthun -- Polymer fusions to increase antibody half-lives : PEGylation and other modifications / Sam P. Heywood and David P. Humphreys -- Extending antibody half-lives with albumin / Jan Terje Andersen and Inger Sandlie -- A stem cell-based platform for the discovery and development of antitumor therapeutic antibodies to novel targets / Jennie P. Mather [and others] -- Antibody directed enzyme prodrug therapy (ADEPT) / Helen L. Lowe [and others] -- Immune privilege and tolerance -- therapeutic antibody approaches / Daron Forman [and others] -- Antibody therapeutics : business achievements and business outlook / Christophe Bourrilly.
520			_aRecombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.
650		0	_aMonoclonal antibodies _xTherapeutic use.
700	1		_aLittle, Melvyn, _d1945- _eeditor.
776	0	8	_iPrint version: _z9780521887328
856	4	0	_uhttps://doi.org/10.1017/CBO9780511596773
999			_c521730 _d521728