000			03822nam a22003618i 4500
001			CR9780511546310
003			UkCbUP
005			20200124160319.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090508s2005||||enk o ||1 0|eng|d
020			_a9780511546310 (ebook)
020			_z9780521836548 (hardback)
020			_z9780521177474 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQP552.M64 _bM64 2005
082	0	0	_a572/.645 _222
245	0	0	_aMolecular chaperones and cell signalling / _cedited by Brian Henderson, A. Graham Pockley.
246	3		_aMolecular Chaperones & Cell Signalling
264		1	_aCambridge : _bCambridge University Press, _c2005.
300			_a1 online resource (xiv, 330 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aChaperone function / R.J. Ellis -- Intracellular disposition of mitochondrial molecular chaperones / R.S. Gupta [and others] -- Novel pathways of protein secretion / G. Chimini, A. Rubartelli -- Moonlighting proteins / C.J. Jeffery -- Molecular chaperones / B. Henderson, A. Shamaei-Tousi -- Cell-cell signalling properties of the chaperonins / A.R.M. Coates -- Toll-like receptor-dependent activation of antigen presenting cells by Hsp60, Hsp70 and Gp96 / R.M. Vabulas, H. Wagner -- Regulation of signal transduction by intracellular and extracellular Hsp70 / A. Asea, S. Calderwood -- Hsp72 and cell signalling / M.Y. Sherman -- Heat shock proteins, their cell surface receptors and effect on the immune system / T. Lehner [and others] -- Molecular chaperone-cytokine interactions at the transcriptional level / A. Stephanou, D.S. Latchman -- Heat shock protein release and naturally-occurring exogenous heat shock proteins / J. Frostegård, A.G. Pockley -- Hsp27 as an anti-inflammatory protein / K. Laudanski, A. De, C. Miller-Graziano -- Bip, a negative immune regulator involved in rheumatoid arthritis / V.M. Corrigal, G.S. Panayi -- Neuroendocrine aspects of the molecular chaperones ADNF and ADNP / I. Gozes [and others] -- Heat shock proteins regulate by both molecular and network cross-reactivity / F.J. Quintana, I.R. Cohen -- Heat shock protein fusions / L. Mizzen, J. Neefe -- Molecular chaperones as inducers of tumour immunity / P.P. Banerjee, Z. Li -- Gazing into the crystal ball / L. Hightower.
520			_aOriginally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
650		0	_aMolecular chaperones.
700	1		_aHenderson, Brian _c(Professor), _eeditor.
700	1		_aPockley, A. Graham _q(Alan Graham), _d1960- _eeditor.
776	0	8	_iPrint version: _z9780521836548
856	4	0	_uhttps://doi.org/10.1017/CBO9780511546310
999			_c521763 _d521761