000			03230nam a22003618i 4500
001			CR9780511546297
003			UkCbUP
005			20200124160319.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090508s2003||||enk o ||1 0|eng|d
020			_a9780511546297 (ebook)
020			_z9780521812405 (hardback)
020			_z9781107403451 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQR100.8.B55 _bM435 2003
082	0	0	_a616/.01 _221
245	0	0	_aMedical implications of biofilms / _cedited by Michael Wilson, Deirdre Devine.
264		1	_aCambridge : _bCambridge University Press, _c2003.
300			_a1 online resource (xiii, 314 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aIntroductory chapters -- Biofilm-dependent regulation of gene expression -- Quorum sensing and microbial biofilms -- Antimicrobial agents and biofilms -- Biofilms on prosthetic devices -- Animal models of orthopaedic implant infection -- Intravascular-catheter-related infections -- Molecular basis of biofilm formation by staphylococcus epidermidis -- Biofilm complications of urinary tract devices -- Oral biofilms -- Novel microscopic methods to study the structure and metabolism of oral biofilms -- Oral streptococcal genes that encode biofilm formation -- Gene expression in oral biofilms -- Biofilms on shedding surfaces -- Dissection of the genetic pathway leading to multicellular behaviour in salmonella enterica serotype typhimurium and other enterobacteriaceae -- Bacterial growth on mucosal surfaces and biofilms in the large bowel -- Pseudomonas aeruginosa biofilms in lung infections.
520			_aHuman tissues often support large, complex microbial communities growing as biofilms that can cause a variety of infections. As a result of an increased use of implanted medical devices, the incidence of these biofilm-associated diseases is increasing: the non-shedding surfaces of these devices provide ideal substrata for colonisation by biofilm-forming microbes. The consequences of this mode of growth are far-reaching. As microbes in biofilms exhibit increased tolerance towards antimicrobial agents and decreased susceptibility to host defence systems, biofilm-associated diseases are becoming increasingly difficult to treat. Not surprisingly, therefore, interest in biofilms has increased dramatically. The application of microscopic and molecular techniques has revolutionised our understanding of biofilm structure, composition, organisation, and activities, resulting in important advances in the prevention and treatment of biofilm-related diseases. The purpose of this book, which was first published in 2003, is to bring these advances to the attention of clinicians and medical researchers.
650		0	_aBiofilms.
650		0	_aMedical microbiology.
700	1		_aWilson, Michael, _d1947 April 12- _eeditor.
700	1		_aDevine, Deirdre, _d1961- _eeditor.
776	0	8	_iPrint version: _z9780521812405
856	4	0	_uhttps://doi.org/10.1017/CBO9780511546297
999			_c521786 _d521784