000			02738nam a22003738i 4500
001			CR9780511535321
003			UkCbUP
005			20200124160324.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090429s2007||||enk o ||1 0|eng|d
020			_a9780511535321 (ebook)
020			_z9780521851213 (hardback)
020			_z9781107424272 (paperback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQP551 _b.G86 2007
082	0	4	_a572.633 _222
100	1		_aGunton, J. D. _q(James D.), _d1937- _eauthor.
245	1	0	_aProtein condensation : _bkinetic pathways to crystallization and disease / _cJ.D. Gunton, A. Shiryayev, and D.L. Pagan.
264		1	_aCambridge : _bCambridge University Press, _c2007.
300			_a1 online resource (xii, 364 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aGlobular protein structure -- Experimental methods -- Thermodynamics and statistical mechanics -- Protein-protein interactions -- Theoretical studies of equilibrium -- Nucleation theory -- Experimental studies of nucleation -- Lysozyme -- Some other globular proteins -- Membrane proteins -- Crystallins and cataracts -- Sickle hemoglobin and sickle cell anemia -- Alzheimer's disease.
520			_aThe quest to understand the condensation of proteins from solutions is a rapidly evolving field. The purpose of this book is to bring to an interdisciplinary audience the state-of-the-art in current research. The first part of the book deals with issues related to the production of high quality protein crystals from solution. Since protein function is determined by structure, high quality protein crystals must be grown in order to determine their structure by X-ray crystallography. The book also discusses diseases that occur due to undesired protein condensation, an increasingly important subject. Examples include sickle cell anemia, cataracts and Alzheimer's disease. Current experimental and theoretical work on these diseases is discussed, which seeks understanding at a fundamental, molecular level, to prevent the undesired condensation from occurring. The book, containing color plate sections, is suitable for graduate students and academic researchers in physics, chemistry, structural biology, protein crystallography and medicine.
650		0	_aProteins.
650		0	_aCondensation.
700	1		_aShiryayev, A. _q(Andrey), _eauthor.
700	1		_aPagan, D. L. _q(Daniel L.), _eauthor.
776	0	8	_iPrint version: _z9780521851213
856	4	0	_uhttps://doi.org/10.1017/CBO9780511535321
999			_c522083 _d522081