000			02764nam a22003618i 4500
001			CR9780511575853
003			UkCbUP
005			20200124160325.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			090522s2009||||enk o ||1 0|eng|d
020			_a9780511575853 (ebook)
020			_z9780521790024 (hardback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQP563.D66 _bC86 2009
082	0	0	_a612.8/042 _222
100	1		_aCumming, Paul, _eauthor.
245	1	0	_aImaging dopamine / _cPaul Cumming.
264		1	_aCambridge : _bCambridge University Press, _c2009.
300			_a1 online resource (xv, 340 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aThe life history of dopamine -- Enzymology of tyrosine hydroxylase -- The assay of tyrosine hydroxylase -- Enzymology of aromatic amino acid decarboxylase -- PET studies of DOPA utilization -- Conjugation and sulfonation of dopamine and its metabolites -- Dopamine synthesis and metabolism rates -- MAO activity in the brain -- Vesicular storage of dopamine -- Dopamine release : from vesicles to behavior -- The plasma membrane dopamine transporter -- Dopamine receptors -- Imaging dopamine D1 receptors -- Imaging dopamine D2 receptors -- Factors influencing D2 binding in living brain -- The absolute abundance of dopamine receptors in brain.
520			_aSince its discovery 50 years ago, brain dopamine has been implicated in the control of movement and cognition, and is concerned with diverse brain diseases such as Parkinson's disease, schizophrenia and drug addiction. This book is an illustrated biography of the dopamine molecule, from its synthesis in the brain to its signalling mechanisms and ultimately to its metabolic breakdown. Using colour illustrations of positron emission tomography (PET) scans, each chapter presents a specific stage in the biochemical pathway for dopamine. Writing for researchers and graduate students, Paul Cumming presents a compilation of all that has been learned about dopamine through molecular imaging, a technology which allows the measurement of formerly invisible processes in the living brain. He reviews current technical controversies in the interpretation of dopamine imaging, and presents key results illuminating brain dopamine in illness and health.
650		0	_aDopamine.
650		0	_aTomography, Emission.
650		0	_aSingle-photon emission computed tomography.
650		0	_aMolecular radiobiology.
776	0	8	_iPrint version: _z9780521790024
856	4	0	_uhttps://doi.org/10.1017/CBO9780511575853
999			_c522170 _d522168