000 02227nam a22003618i 4500
001 CR9780511524721
003 UkCbUP
005 20200124160326.0
006 m|||||o||d||||||||
007 cr||||||||||||
008 090402s1995||||enk o ||1 0|eng|d
020 _a9780511524721 (ebook)
020 _z9780521451840 (hardback)
020 _z9780521675574 (paperback)
040 _aUkCbUP
_beng
_erda
_cUkCbUP
050 0 0 _aQP624.5.S73
_bP76 1995
082 0 0 _a574.87/3282
_220
100 1 _aProhofsky, Earl,
_eauthor.
245 1 0 _aStatistical mechanics and stability of macromolecules :
_bapplication to bond disruption, base pair separation, melting, and drug dissociation of the DNA double helix /
_cEarl Prohofsky.
246 3 _aStatistical Mechanics & Stability of Macromolecules
264 1 _aCambridge :
_bCambridge University Press,
_c1995.
300 _a1 online resource (x, 227 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
520 _aThis book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.
650 0 _aDNA
_xStability
_xStatistical methods.
650 0 _aMacromolecules
_xStability
_xStatistical methods.
650 0 _aStatistical mechanics.
776 0 8 _iPrint version:
_z9780521451840
856 4 0 _uhttps://doi.org/10.1017/CBO9780511524721
999 _c522226
_d522224