000			01937nam a22003737a 4500
999			_c526297 _d526295
001			4731758
003			Ge_NSL
005			20200210125035.0
008			840227s1985 us a b 001 0 eng
010			_a 84004172
020			_a0716716143
020			_a0716716151 (pbk.)
040			_aDLC _cDLC _dDLC
041			_aeng
050	0	0	_aQP601 _b.F42 1985
060			_aQU 135 F399e
080			_a577.15
082	0	0	_a574.19/25 _219
100	1		_aFersht, Alan, _d1943- _9148793
245	1	0	_aEnzyme structure and mechanism / _cAlan Fersht.
250			_a2nd ed.
260			_aNew York : _bW.H. Freeman, _cc1985.
300			_axxi, 475 p. : _bill. ; _c25 cm.
504			_aIncludes bibliographies and index.
505			_aContents: The three-dimensional structure of enzymes -- Chemical catalysis -- The basic equations of enzyme kinetics -- Management and magnitude of enzymatic rate constants -- The pH dependence of enzyme catalysis -- Practical kinetics -- Detection of intermediates in reactions by kinetics -- Stereochemistry of enzymatic reactions -- Active-site-directed and enzyme-activated irreversible inhibitors: "affinity labels" and "suicide inhibitors" -- Cooperative ligand binding, allosteric interactions, and regulation -- Forces between molecules, and enzyme-substrate binding energies -- Enzyme-substrate complementarity and the use of binding energy in catalysis -- Specificity and editing mechanisms -- Genetic engineering and enzymology: protein engineering -- Structures and mechanisms of selected enzymes.
650		0	_aEnzymes. _9148794
650		2	_aEnzymes. _9148794
653			_aბიოლოგია
653			_aბიოქიმია
653			_aენზიმები - სტრუქტურა და მექანიზმი
653			_aენზიმოლოგია
906			_a7 _bcbc _corignew _d1 _eocip _f19 _gy-gencatlg
942			_2udc _cBK